Dr. Collins is the Termeer Professor of Medical Engineering and Science in the Institute for Medical Engineering and Science as well as Professor of Biological Engineering at Massachusetts Institute of Technology. He is one of the founders of the field of synthetic biology, has been elected to all three national academies—the National Academy of Sciences, National Academy of Engineering and National Academy of Medicine—and has received a number of awards recognizing his work, including the Dickson Prize in Medicine and the Sanofi-Institut Pasteur Award. Dr. Collins has been a Rhodes Scholar, a MacArthur Fellow and a recipient of the NIH Pioneer Award. In addition to his role as a faculty member at MIT, Dr. Collins is a Core Faculty member of the Wyss Institute at Harvard and an Institute Member of the Broad Institute of MIT and Harvard. Dr. Collins is a co-founder of Synlogic, Sherlock Biosciences, Cellarity and Phare Bio, and serves on the SAB of multiple companies including Danaher and Shape Therapeutics. Dr. Collins has a PhD in Medical Engineering from the University of Oxford, and an AB in Physics from the College of the Holy Cross.

Dr. Andreeff is a Professor of Medicine and holds the Paul and Mary Haas Chair in Genetics at the University of Texas MD Anderson Cancer Center. He has worked extensively on drug resistance in hematopoietic malignancies, such as acute myelogenous leukemia (AML), and developed or co-developed several new therapeutic agents. Dr. Andreeff has an MD and PhD from the University of Heidelberg Medical School, and additional training and faculty appointments at the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York in the Departments of Pathology and Leukemia.

Dr. Kalos is an independent advisor and consultant as well as an internationally recognized expert in T cell therapy, oncology vaccines and immuno-oncology with over 25 years of experience in both industry and academia. He has served in leadership and executive roles at Janssen, Eli Lilly and most recently at Arsenal Bio. Prior to industry, Dr. Kalos spent 10 years in academia, including founding and directing the Translational and Correlative Studies Laboratory at the University of Pennsylvania that played a key role in the development of the CTL019 program that was licensed to Novartis and commercialized as Kymriah, the first approved CAR-T cell therapy product. Dr. Kalos has a PhD from the University of Minnesota and completed post-doctoral training in the laboratory of Phil Greenberg at the Fred Hutchinson Cancer Research Center. He has over 85 peer-reviewed publications including multiple high-impact and field-defining manuscripts, and over 26 issued patents in the fields of cell therapy, immunotherapy and vaccines.

Dr. Taylor is an independent consultant with two decades of biopharma experience in global development and commercialization of oncology drugs. Most recently he was the Chief Commercial Officer at Seagen, leading the organization for the launches of PADCEV (enfortumab vedotin) and Tukysa (tucatinib). He began his career at Genentech with leadership roles in Product Marketing, where he contributed to the success of several leading brands, including HERCEPTIN® (trastuzumab), AVASTIN® (bevacizumab) and ALECENSA® (alectinib). Subsequently, he was the Franchise Head for Immuno-Oncology (IO) at both Genentech/Roche and AstraZeneca, gaining significant experience in development and commercialization of IO therapies, including TECENTRIQ® (atezolizumab) and IMFINZI® (durvalumab). He earned a PhD in Molecular and Medical Genetics from the University of Toronto, an MBA from the University of California, Berkeley, and a BSc from the University of British Columbia.

Dr. Trager is a well-established biotechnology leader deeply versed in the development and application of cellular therapies for cancer. He brings to Senti Bio over 25 years of technical expertise, strategic execution and development of novel cellular and biologic therapies. In addition to his industry positions, he also serves as an advisor for the Shoreline Community College Immunotherapy Biohub and SPARK at Stanford. Over the course of his career, he has contributed to nearly 50 publications, abstracts and patents.

Dr. Trager formerly served as the Chief Scientific Officer of Nkarta Therapeutics where he led the development of multiple discovery assets through IND and the creation of a pipeline of CAR NK product opportunities. Prior to his role at Nkarta, Dr. Trager held a number of increasing roles and responsibilities at Dendreon Pharmaceuticals, Inc., most recently having served as Vice President of Research and Product Development, where he was responsible for product and biomarker development development activities, supporting the late stage development of sipuleucel-T through clinical study, approval, and commercialization. Prior to that, Dr. Trager served as a Senior Scientist at Geron Corporation, where he was part of the team that cloned human telomerase, and enabled the manufacture and clinical development of a telomerase inhibitor. Across his career, he managed and integrated the efforts of over 100 scientists, engineers and technicians contributing to the invention and development of multiple cell therapies.

Dr. Trager holds a BA from St. John’s College in Santa Fe New Mexico and his Ph.D. in Molecular Biology and Biochemistry from the University of California at Berkeley.

Dr. Varney is the Chairman of R&D, SAB Member and Board Director at Erasca, an early-stage biotechnology company on a mission to erase cancer by shutting down key cancer pathways. Dr. Varney is a pioneer drug discoverer and biotech leader—he has led research and early drug development efforts at Agouron, the developers of an early HIV protease inhibitor, Viracept^®, as well as multiple approved anti-cancer agents, including Xalkori^® (crizotinib) and Inlyta^® (axitinib). Dr. Varney was instrumental in expanding Genentech’s drug discovery capabilities to include small molecules, building an organization that produced anti-cancer drugs Erivedge^® (vismodegib) and Cotellic^® (cobimetinib). He most recently retired from Genentech as the Head of Research and Early Development. Dr. Varney has a BS in Chemistry from the University of California, Los Angeles, and a PhD in synthetic organic chemistry from the California Institute of Technology. He was an American Cancer Society postdoctoral fellow at Columbia University.