Aiming to outsmart complex diseases with more intelligent medicines
Senti Bio’s mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. Senti Bio designs and optimizes gene circuits, which are created from novel and proprietary combinations of DNA sequences, to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments.
Senti Bio is applying its gene circuit technologies to develop an internal pipeline of medicines that use allogeneic (CAR-NK) cells with the goal of addressing major challenges for people living with cancer.
The Senti Bio gene circuit platform has the potential to usher in the next wave of medicine.
Building more control into everything we do
We use gene circuit platform technologies to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. Gene circuits program cells to sense key biological signals, compute based on this information and dynamically respond with multiple therapeutic outputs. We use a Design-Build-Test-Learn development engine to design therapeutic gene circuits that may be engineered into product candidates.
The field of synthetic biology has evolved rapidly over the past few decades — we believe that we are uniquely positioned to harness its potential to drive significant advances in medicine.
Tim Lu, CEO
Engineering smarter medicines
by programming cells with gene circuits
Senti Bio is primarily focused on advancing a broad pipeline of gene circuit-enabled product candidates focused on three distinct categories: allogeneic CAR-NK cells for oncology, gene therapies for tissue-directed targets, and cell therapies for regenerative medicines. Senti Bio’s allogeneic CAR-NK product candidates are designed to improve the therapeutic outcome of certain oncology indications. Senti Bio believes that its gene circuit platform technologies can be used against a broad range of diseases that span therapeutic areas such as oncology, immunology, neuroscience, cardiovascular disease, regenerative medicine and genetic disease.