Scientific Presentations & Publications
Senti Bio's team is pioneering the use of gene circuits for potentially broad therapeutic application. The publications highlighted below represent a sample of the team's innovative and foundational work.
Authors: Deepika Kaveri, Pearley Chinta, Elizabeth Leitner, Lawrence Naitmazi, Gozde Yucel, Mengxi Tian, Niran Almudhfar, Han Deng, Yongshuai Li, Alice Lam, Chen-Ting Lee, Enping Hong, Rochelle Emery, Brian Garrison, Aaron N. Nguyen, and Kanya Rajangam
Authors: Muharrem Muftuoglu, Mahesh Basyal, Li Li Jiangxing, Lauren B. Ostermann, Ran Zhao, Baozhen Ke, Hiroki Akiyama, Po Yee Mak, Bing Z. Carter, Han Deng, Yongshuai Li, Brian S. Garrison, Kanya L. Rajangam, Michael Andreeff
Authors: Frances D. Liu, Michelle Hung, Assen Roguev, Yin Yin Chong, Cesar Juarez, Russell M. Gordley, Mark Tomishima, Jessica M Haverkamp, Panos Douvaras, Alex Danza, Monika Avina, Timothy K. Lu, and Philip Lee
Authors: Rebecca T. Cottman, Vanessa Johnson, Michelle Hung, Yin Yin Chong, Eren Chu, Assen Roguev, Marcus Gainer, Joseph Sperling, Monika Avina, Brett Kiedaisch, Raghav Kannan, Chandra Verma, Chew-Li Soh, Conor McAuliffe, Mark Tomishima, Russell M. Gordley, Timothy K. Lu, and Philip Lee
Authors: Nicholas W. Frankel, Assen Roguev, Marcus Gainer, Han Deng, Priscilla Wong, Gozde Yucel, Alice Lam, Yongshuai Li, Michelle Hung, Derrick Lee, Chen-Ting Lee, Andrew Banicki, Mengxi Tian, Niran Almudhfar, Wenqi Song, Lawrence Naitmazi, Brian Garrison, Kanya Rajangam, Timothy K. Lu
Authors: Tony Hua, Nicholas W. Frankel, Ippolito I. Caradonna, Assen Roguev, Karen L. Chu, Russell M. Gordley, Kanya Rajangam and Timothy K. Lu
Authors: Chew-Li Soh, Rebecca Cottman, Conor McAuliffe, Vanessa Johnson, Michelle Hung, Yin Yin Chong, Noah Jacobs-Rebhun, Cloe Grace, Jeffrey Levin, Tackla Winston, Mark Ebel, Eren Chu, Assen Roguev, Russell Gordley, Tim Lu, Mark Tomishima
Authors: Joseph Draut, Thant Zaw, Myles MacEachern, Magdalena Cichewicz, Assen Roguev, Jang Hwan Cho, Daniel M. Cohen, Laura Barrio Real, Shreyasi Choudhury, Ali Nahvi, Jed Chatterton, Virginia A. Haurigot, Sean M. Armour, Federico Mingozzi, Rocky Chueng, Michelle Hung, Frances Liu, Rebecca Cottman, Nicholas Frankel, Tony Hua, Gary K. Lee, Curt Herberts, Philip Lee, Timothy Lu, Russell Gordley
Authors: Rebecca Cottman, Vanessa Johnson, Michelle Hung, Yin Yin Chong, Andrew Banicki, Mengxi Tian, Chen -Ting Lee, Eren Chu, Assen Roguev, Monika Avina, Alex Danza, Brett Kiedaisch, Raghav Kannan, Chandra Verma, Chew -Li Soh, Conor McAuliffe, Mark Tomishima, Russell Gordley, Gary Lee, Tim Lu
Authors: Nicholas W. Frankel, Ippolito I. Caradonna, Marcus A. Gainer, Junjie Tony Hua, Brian Garrison, Russell M. Gordley, Timothy K. Lu
Authors: Frances D. Liu, Michelle Hung, Assen Roguev, Yin Yin Chong, Eniola Catton, Jessica Haverkamp, Panos Douvaras, Alex Danza, Monika Avina, Mark Tomishima, Russell Gordley, Gary K. Lee, Timothy Lu
Authors: Kelly Chen-Ting Lee, Michelle Hung, Andrew Banicki, Wenqi Song, Niran Almudhfar, Deepika Kaveri, Priscilla Wong, Lawrence Naitmazi, Marcela Guzman, Alice Lam, Gozde Yucel, Timothy Lu, Alba Gonzalez Junca, Brian Garrison and Philip Lee
Authors: Alba Gonzalez, Enping Hong, GozdeYucel, Elizabeth Leitner, PearleyChinta, Han Deng, Ian Li, Alice Lam, AblaBakir, Brandon Lee, PapiaChakraborty, Carmina Blanco, Chen-Ting Lee, NiranAlmudhfar, MengxiTian, WenqiSong, Andrew Banicki, Otto Contreras, Martin Gieldin, Brian Garrison, Timothy K. Lu, Kanya Rajangam
Authors: Deepika Kaveri, Enping Hong, Elizabeth Leitner, Priscilla Wong, Ronni Ponek, Lawrence Naitmazi, Pearley Chinta, Wesley Gorman, Mengxi Tian, Niran Almudhfar, Kelly Lee, Nicholas Frankel, Russell Gordley, Philip Lee, Alba Gonzalez Junca, Timothy Lu, Kanya Rajangam, Marcela Guzman Ayala
Authors: Brian Garrison, Han Deng, Gozde Yucel, Nicholas Frankel, Russell Gordley, Michelle Hung, Derrick Lee, Marcus Gainer, Assen Roguev, Wesley Gorman, Nelia Leemans, Alice Lam, Yongshuai Li, Wilson Wong, Kanya Rajangam, Philip Lee, Timothy Lu
Authors: Marcela Guzman Ayala, Michelle Hung, Deepika Kaveri, Rebecca Cottman, Enping Hong, Elizabeth Leitner, Priscilla Wong, Ronni Ponek, Lawrence Naitmazi, Manan Shah, Wesley Gorman, Andrew Banicki, Mengxi Tian, Niran Almudhfar, Kelly Lee, Russell Gordley, Philip Lee, Timothy Lu
Authors: Nicholas Frankel, Maelig Morvan, Assen Roguev, Michelle Hung, Russell Gordley, Miguel Palermo, Tyler Santomasso, Pearley Chinta,Aldo Sotelo, Marcus Gainer, Derrick Lee, Tony Hua, Cheng-Ting Lee, Andrew Banicki, Mengxi Tian, Niran Almudhfar, Otto Contreras, Tim Lu, Alba Gonzalez
Authors: Brian Garrison , Han Deng, Gozde Yucel, Nicholas Frankel, Russell Gordley, Michelle Hung, Derrick Lee, Marcus Gainer, Nelia Leemans, Alice Lam, Wilson Wong, Philip Lee, Tim Lu, Gary Lee
Abstract 844: click here
Authors: Marcela Guzman Ayala, Michelle Hung, Poornima Ramkumar, Deepika Kaveri, Elizabeth Leiner, Priscilla Wong, Ronni Ponek, Brett Kiedaisch, Wesley Gorman, Russell Gordley, Rebecca Cottman, Kelly Lee, Allison Drain, Ahmad S Khalil, Gary Lee
Authors: Michelle Hung, Assen Roguev, Yin Yin Chong, Carmina Blanco, Travis Wood, Brandon Lee, Brett Kiedaisch, Russell Gordley, Gary Lee, Tim Lu
Authors: Travis Wood, Abla Bakir, Carmina Blanco, Dharini Iyer, Wesley Gorman, Haritha Lakshmireddy, Charity Vilchez Juang, Denny Nguyen, Martin Giedlin, Philip Lee
Authors: Alba Gonzalez, Michelle Hung, Marcela Guzman, Aldo Sotelo, Nicholas Frankel, Yin-Yin Chong, Deepika Kaveri, Poornima Ramkumar, Elizabeth Leiner, Priscilla Wong, Ronni Ponek, Kelly Lee, Alyssa Mullenix, Russell Gordley, Gary Lee
Authors: Brian S. Garrison, PhD , Han Deng, PhD, Gozde Yucel , PhD, Nicholas W. Frankel, PhD, Marcela Guzman Ayala, PhD, Russell Gordley, PhD, Michelle Hung, PhD, Derrick Leem, Marcus Gainer, Kathryn Loving, PhD, Jenny Chien, Tiffany Pan, MS, Wesley Gorman, Nelia Leemans , MS, Alice Lam, Poornima Ramkumar, PhD, Travis Wood, Wilson Wong, PhD, Philip Lee, PhD, Tim Lu, MD PhD, Gary Lee, PhD
Authors: Alba Gonzalez, Assen Roguev, Brian Garrison, Nicholas Frankel, Derrick Lee, Marcus Gainer, Alyssa Mullenix, Russel Gordley, Kathryn Loving, Jenny Chien, Gary Lee
Authors: Dharini Iyer, Wesley Gorman, Carmina Blanco, Travis Wood, Mario Lorente, Charity Vilchez Juang, Denny Nguyen, Brandon Lee, Brett Kiedaisch, Philip Lee
Authors: Travis Wood, Abla Bakir, Carmina Blanco, Dharini Iyer, Brett Kiedaisch, Wesley Gorman, Mario Lorente, Brandon Lee, Denny Nguyen, Philip Lee
Authors: Michelle Hung, Divya Israni, Huishan Li, Yin Yin Chong, Poornima Ramkumar , Allison Drain, Allison Quach, Mengxi Tian, Rishi Savur, Niran Almudhfar, Chen Ting Lee, Abla Bakir, Edwin Cruz, Carmina Blanco, Travis Wood, Mario Lorente, Brandon Lee, Brett Kiedaisch, Russell M. Gordley, Marcela Guzman Ayala, Ahmad Khalil, Gary Lee, Tim Lu
Authors: Brian S. Garrison, Han Deng, Gozde Yucel , Nicholas W. Frankel, Marcela Ayala Guzman, Russell M. Gordley , Michelle Hung, Derrick Lee, Marcus Gainer, Kathryn Loving, Jenny Chien , Tiffany Pan, Wesley Gorman, Nelia Leemans , Alice Lam, Travis Wood, Wilson Wong, Philip Lee, Tim Lu, Gary Lee
Nicholas W. Frankel, Seunghee Lee, Derrick Lee, Marcus Gainer, Brian S. Garrison, Travis Wood,Wesley Gorman, Russell Gordley, Marcela Guzman Ayala, Tim Lu, Gary Lee, Wison Wong
Authors: Alba Gonzalez-Junca, Assen Roguev, Brian Garrison, Nicholas Frankel, Derrick Lee, Marcus Gainer, Alyssa Mullenix, Russell Gordley, Kathryn Loving, Jenny Chien, Gary Lee
Cho JH, Collins JJ, Wong WW. Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses. Cell 173:1426 (2018). doi: 10.1016/j.cell.2018.03.038.
Wilson Wong and co-authors introduce a unique split/universal chimeric antigen receptor (CAR) targeting system called SUPRA that affords tunable control over immune cell activity via soluble antigen-binding molecules. SUPRA CAR can fine-tune immune cell activation strength to mitigate toxicity, SUPRA CAR can sense and logically respond to multiple antigens to prevent relapse and enhance safety, and SUPRA CAR can inducibly control cell-type-specific signaling.
Scheller L, Strittmatter T, Fuchs D, Bojar D, Fussenegger M. Nature Chemical Biology 14:723 (2018). doi: 10.1038/s41589-018-0046-z.
Here, Martin Fussenegger and coworkers describe a novel generalized extracellular molecule sensing (GEMS) protein architecture that, working in conjunction with synthetic promoters, can be adapted to detect a wide diversity of inputs including soluble signals. Examples of input signals detected here include the synthetic azo dye, nicotine, a peptide tag, and the PSA (prostate-specific antigen) biomarker.
Nissim L, Wu MR, Pery E, Binder-Nissim A, Suzuki H, Stupp D, Wehrspaun C, Tabach Y, Sharp PA, Lu TK. Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell 171:1138 (2017). doi: 10.1016/j.cell.2017.09.049.
In this publication, Tim Lu and co-workers present a proof-of-concept immunomodulatory gene circuit platform that enables tumor-specific expression of immunostimulators. Tumor-specific expression was achieved using synthetic cancer-specific promoters and an RNA-based AND gate that generates combinatorial immunomodulatory outputs only when two promoters are mutually active. In preclinical models, a lentiviral cancer gene therapy encoding this gene circuit triggered tumor-specific expression, recruitment of T cells, and immune-mediated elimination of tumors.
Saxena P, Heng BC, Bai P, Folcher M, Zulewski H, Fussenegger M. A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells. Nature Communications 7: 11247 (2016). doi: 10.1038/ncomms11247.
While recent advances in regenerative medicine have permitted the generation of off-the-shelf tissue grafts suitable for a wide variety of medical applications, the low efficiency and high cost of cellular differentiation protocols represent significant hurdles. In this work, Martin Fussenegger and coworkers describe a gene circuit approach that relies on low-cost inputs (like vanillic acid, a relative of the primary extract component of vanilla bean) to efficiently control the derivation of functional pancreatic insulin-producing cells from precursor cells for the treatment of Type 1 diabetes.
Schukur L, Geering B, Charpin-El Hamri G, Fussenegger M. Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis. Science Translational Medicine 7:318 (2015). doi: 10.1126/scitranslmed.aac4964.
Psoriasis is a chronic inflammatory skin disease characterized by a relapsing-remitting disease course and correlated with increased expression of proinflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin 22 (IL-22). Psoriasis is hard to treat because of the unpredictable and asymptomatic flare-up, which limits handling of skin lesions to symptomatic treatment. Here, Martin Fussenegger and colleagues designed a mammalian cell synthetic cytokine converter that quantifies psoriasis-associated TNF and IL-22 levels using serially linked receptor-based synthetic signaling cascades, processes the levels of these proinflammatory cytokines with AND-gate logic, and triggers the corresponding expression of therapeutic levels of the anti-inflammatory/psoriatic cytokines IL-4 and IL-10, which have been shown to be immunomodulatory in patients.
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