New generation of
smarter medicines

Developing differentiated
cancer therapeutics

Senti Bio is a clinical-stage company founded to create a new generation of smarter medicines for patients living with incurable diseases. To achieve this, we use synthetic biology to design and optimize proprietary Gene Circuits. Senti Bio’s Gene Circuits are created from novel combinations of DNA sequences to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. Using Gene Circuits, our therapeutics are designed to precisely kill cancer cells, spare healthy cells, increase specificity to target cells and control the expression of drugs even after administration.

We are applying our Gene Circuit technologies to develop a pipeline of product candidates that use cell therapy with the goal of addressing major challenges and providing potentially lifesaving treatments for people living with cancer.

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Engineering smarter
medicines by programming
cells with Gene Circuits

Senti Bio is primarily focused on advancing cell therapy programs for oncology indications. Our lead product candidate SENTI-202 is in the clinic in the U.S. for the treatment of acute myeloid leukemia (AML).

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“The field of synthetic biology has evolved rapidly over the past few decades. We believe that we are uniquely positioned to harness its potential to drive significant advances in medicine.”

Tim Lu, MD, PhD
Co-Founder and CEO, Senti Bio

Better together.
Always learning.

Be a part of the world-class team at Senti Bio and help engineer what’s next.

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