Complex diseases require smarter medicines.

Senti Bio is building a synthetic biology platform that could enable it to program next-generation cell and gene therapies with “gene circuits.” Senti Bio’s lead product candidates utilize allogeneic chimeric antigen receptor natural killer (CAR-NK) cells outfitted with gene circuit technologies in several oncology indications with high unmet need.
Gene Circuit Engineering: Pursuing New Classes of Cell and Gene Therapies

Gene circuits are created from novel and proprietary combinations of DNA sequences in order to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. Senti Bio believes that its approach to programming gene circuits is broadly applicable toward engineering optimal efficacy, precision and control into many cell or gene based medicines.

Senti Bio’s perspective on how our gene circuit technologies could enable the creation of smarter medicines that can “sense inputs,” “compute decisions” and “respond with outputs” to impact disease.